B. Colzani, L. Pandolfi, A. Hoti, P.A. Iovene, A. Natalello, S. Avvakumova, M. Colombo, D. Prosperi Investigation of antitumor activities of trastuzumab delivered by PLGA nanoparticles. Int. J. Nanomed.  2018, 13, 957

B. Riva, M. Bellini, E. Corvi, P. Verderio, E. Rozek, B. Colzani, S. Avvakumova, A. Radeghieri, M.A. Rizzuto, C. Morasso, M.Colombo, D. Prosperi Impact of the strategy adopted for drug loading in nonporous silica nanoparticles on the drug release and cytotoxic activity. J. Coll. Int. Scie. 2018, 519, 18.



L. Salvioni, E. Galbiati, V. Collico, G. Alessio, S. Avvakumova, F. Corsi, P. Tortora, D. Prosperi*, M. Colombo* Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations. Int. J. Nanomed. 2017, 12, 2517.

U.M. Musazzi, B. Santini, F. Selmin, V. Marini, F. Corsi, R. Allevi, D. Prosperi, F. Cilurzo, M. Colombo*, P. Minghetti* Impact of semi-solid formulations on skin penetration of iron oxide nanoparticles. Nanobiotechnol. 2017, 15, 14.

P. Rainone, B. Riva, S. Belloli, F. Sudati, M. Ripamonti, P. Verderio, M. Colombo, B. Colzani, M. C. Gilardi, R. M. Moresco, D. Prosperi Development of 99mTc-Radiolabeled nanosilica for Targeted Detection of HER2-Positive Breast Cancer. Int. J. Nanomed. 2017, 12, 3447.

E. Cova, S. Inghilleri, L. Pandolfi, M. Morosini, S. Magni, M. Colombo, D. Piloni, C. Finetti, G. Ceccarelli, L. Benedetti, M.G. Cusella, M. Agozzino, F. Corsi, R. Allevi, S. Mrakic-Sposta, S. Moretti, S. De Gregori, D. Prosperi, F. Meloni Bioengineered gold nanoparticles targeted to mesenchymal cells from patients with bronchiolitis obliterans syndrome does not rise the inflammatory response and can be safely inhaled by rodents. Nanotoxicology. 2017, 11, 534.

M. Truffi§, M. Colombo§, J. Peñaranda-Avila, L. Sorrentino, F. Colombo, M. Monieri, V. Collico, P. Zerbi, E. Longhi, R. Allevi, D. Prosperi, F. Corsi Nano-targeting of mucosal addressin cell adhesion molecule-1 identifies bowel inflammation foci in murine model. Nanomedicine 2017, 12, 1547.

L. Pandolfi, M. Bellini, R. Vanna, C. Morasso, A. Zago, S. Carcano, S. Avvakumova, J.A. Bertolini, M. A. Rizzuto, M. Colombo, D. Prosperi H‑Ferritin Enriches the Curcumin Uptake and Improves the Therapeutic Efficacy in Triple Negative Breast Cancer Cells. Biomacromolecules 2017, 18, 3318.

M.R. Marinozzi, L. Pandolfi, M. Malatesta, M. Colombo, V. Collico, P. M-J. Lievens, S. Tambalo, C. Lasconi, F. Vurro, F. Boschi, S. Mannucci, A. Sbarbati, D. Prosperi, L. Calderan Innovative approach to safely induce controlled lipolysis by superparamagnetic iron oxide nanoparticles-mediated hyperthermic treatment. Int. J. Biochem. Cell Biol. 2017, 93, 62.

D. Prosperi, M. Colombo, I. Zanoni, F. Granucci Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases. Semin Immunol. 2017, 34, 61.



A. Orlando, M. Colombo, D. Prosperi, Fabio Corsi, A. Panariti, I. Rivolta, M. Masserini, E. Cazzaniga Evaluation of gold nanoparticles biocompatibility: a multiparametric study on cultured endothelial cells and macrophages. J. Nanopart. Res., 2016, 18, 58.

L. Salvioni, L. Fiandra, M.D. Del Curto, S. Mazzucchelli, R. Allevi, M. Truffi, L. Sorrentino, B. Santini, M. Cerea, L. Palugan, F.Corsi, M. Colombo Oral delivery of insulin via polyethylene imine-based nanoparticles for colonic release allows glycemic control in diabetic rats. Pharmacol. Res., 2016, 110, 122.

C. Finetti, L. Sola, M. Pezzullo, D. Prosperi, M. Colombo, B. Riva, S. Avvakumova, C. Morasso, S. Picciolini, M. Chiari Click chemistry immobilization of antibodies on polymer coated gold nanoparticles. Langmuir, 2016, 32, 7435.

R. Vago, V. Collico, S. Zuppone, D. Prosperi, M. Colombo Nanoparticle-mediated delivery of suicide genes in cancer therapy. Pharmacol. Res., 2016, 111, 619.

S. Avvakumova, E. Galbiati, L. Sironi, S.A. Locarno, L. Gambini, C. Macchi, L. Pandolfi, M. Ruscica, P. Magni, M. Collini, M. Colombo, F. Corsi, G. Chirico, S. Romeo, D. Prosperi. Theranostic nanocages for imaging and photothermal therapy of prostate cancer cells by active targeting of neuropeptide-y receptor. Bioconj. Chem. 2016, 12, 2911.

M. Colombo, L. Fiandra, G. Alessio, S. Mazzucchelli, M. Nebuloni, C. De Palma, K. Kantner, B. Pelaz, R. Rotem, F. Corsi, W.J. Parak, D. Prosperi. Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies.  Nat. Commun. 2016, 7, 13818.



E. Cova§, M. Colombo§, S. Inghilleri, M. Morosini, S. Miserere, J. Peñaranda-Avila, B. Santini, D. Piloni, S. Magni, F. Gramatica, D. Prosperi, F. Meloni Antibody-engineered nanoparticles selectively inhibit mesenchymal cells isolated from patients with chronic lung allograft dysfunction Nanomedicine, 2015,10, 9-23.

E. Galbiati, M. Cassani, P. Verderio, E. Martegani, M. Colombo, P. Tortora, S. Mazzucchelli, D. Prosperi Peptide-nanoparticle ligation mediated by cutinase fusion for the development of cancer cell-targeted nanoconjugates. Bioconjugate Chem., 2015, 26, 680-689.

L. Fiandra, M. Colombo, S. Mazzucchelli, M. Truffi, B. Santini, R. Allevi, M. Nebuloni, A. Capetti, G. Rizzardini, D. Prosperi, F. Corsi Nanoformulated enfuvirtide crosses the blood-brain barrier in mice. Nanomedicine: NBM, 2015, 6,1387-1397.

B. Santini, I. Zanoni, R. Marzi, C. Cigni, M. Bedoni, F. Gramatica, L. Palugan, F. Corsi, F. Granucci, M. Colombo Cream Formulation Impact on Topical Administration of Engineered Colloidal Nanoparticles. PLoS One, 2015, DOI: 10.1371/journal.pone.0126366.

A. Orlando, M. Colombo, D. Prosperi, M. Gregori, A. Panariti, I. Rivolta, M. Masserini, E. Cazzaniga Iron oxide nanoparticles surface coating and cell uptake affect biocompatibility and inflammatory responses of endothelial cells and macrophages. J. Nanopart. Res., 2015, 17, 351.



C. Morasso, D. Mehn, R. Vanna, M. Bedoni, E. Forvi, M. Colombo, D. Prosperi, F. Gramatica One-step synthesis of star-like gold nanoparticles for surface enhanced raman spectroscopy. Mat. Chem. Phys., 2014, 143, 1215–1221.

C. Finetti, M. Colombo, D. Prosperi, G. Alessio, C. Morasso, L. Sola, M. Chiari.  One-pot phase transfer and surface modification of CdSe/ZnS quantum dots by a synthetic functional copolymer.  Chem. Commun., 2014, 50, 240-242.

S. Avvakumova, M. Colombo, P. Tortora, D. Prosperi. Biotechnological approaches toward nanoparticle biofunctionalization. Trends Biotechnol., 2014, 31, 11-20.

P. Verderio, S. Avvakumova, G. Alessio, M. Bellini, M. Colombo, E. Galbiati, S. Mazzucchelli, J. Peñaranda Avila, B. Santini, D. Prosperi. Delivering colloidal nanoparticles to mammalian cells: a nano-bio interface perspective. Adv. Healthcare Mat., 2014 3, 957-976.

S. Avvakumova, P. Fezzardi, L. Pandolfi, M. Colombo, F. Sansone, A. Casnati, D. ProsperiGold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells. Chem. Commun., 2014, 50, 11029-11032.

P. Verderio, L. Pandolfi, S. Mazzucchelli, M. R. Marinozzi, R. Vanna, F. Gramatica, F. Corsi, M. Colombo, C. Morasso, D. Prosperi Antiproliferative effect of ASC-J9 delivered by PLGA nanoparticles against estrogen-dependent breast cancer cells. Mol. Pharm., 2014, 11, 2864-2875.

S. Sommaruga, E. Galbiati, J. Peñaranda-Avila, C. Brambilla, P. Tortora, M. Colombo, D. Prosperi Immobilization of carboxypeptidase from Sulfolobus solfataricus on magnetic nanoparticles improves enzyme stability and functionality in organic media BMC Biotech., 2014, 14:82;

M. Bellini, S. Mazzucchelli, E. Galbiati, S. Sommaruga, L. Fiandra, Truffi M., M. Colombo, P. Tortora, F. Corsi, D. Prosperi Protein nanocages for self-triggered nuclear delivery of DNA-targeted chemotherapeutics in cancer cells.  J. Controlled Rel., 2014, 196, 184-196.IF = 7.705; codice Scopus: 2-s2.0-84908345916; Doi: 10.1016/j.jconrel.2014.10.002



S. Mazzucchelli, M. Colombo, P. Verderio, E. Rozek, F. Andreata, E. Galbiati, P. Tortora, F. Corsi, D. Prosperi Orientation-controlled conjugation of halo-fused homing peptides to multifunctional nanoparticles for specific recognition of cancer cells. Angew. Chem., Int. Ed. 2013, 52, 3121-3125.

G. Sancini, M. Gregori, E. Salvati, I. Cambianica, F. Re, F. Ornaghi, M. Gobbi, M. Canovi, C. Fracasso, A. Cagnotto, M. Salmona, M. Colombo, C. Zona, B. La Ferla, F. Nicotra, M. Masserini Functionalization with TAT-peptide enhances blood-brain barrier crossing in-vitro of nanoliposomes carrying a curcumin-derivative to bind Alzheimer Aβ peptide. J. Nanomedic. Nanotechnol., 2013, 4, 171.         

P. Verderio, P. Bonetti, M. Colombo, L. Pandolfi, D. Prosperi Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. Biomacromol., 2013, 14, 672−682.

S. Mazzucchelli, S. Sommaruga, M. O’Donnell, P. Galeffi, P. Tortora, D. Prosperi, M. Colombo Dependence of Nanoparticle-Cell Recognition Efficiency from Surface Orientation of ScFv Targeting Ligands. Biomat. Science, 2013, 1, 728-735.

L. Fiandra, S. Mazzucchelli, C. De Palma, M. Colombo, R. Allevi, S. Sommaruga, D. Prosperi, F. Corsi Assessing the In Vivo Targeting Efficiency of Multifunctional Nanoconstructs Bearing Antibody-Derived Ligands. ACS Nano, 2013, 7, 6092-6102.

E. Moschini, M. Gualtieri, M. Colombo, U. Fascio, M. Camatini, P. Mantecca The modality of cell-particle interactions drives the toxicity of nanosized CuO and TiO2 in human alveolar epithelial cells. Toxicology let. 2013, 2, 102-116.

S. Mazzucchelli, M. Colombo, E. Galbiati, F. Corsi,  J.M. Montenegro,W.J. Parak, D. ProsperiO6-alkylguanine-DNA transferase (SNAP) as capture module for site-specific covalent bioconjugation of targeting protein on nanoparticles. Progress in biomedicaloptics and imaging, 2013, 8595, 859502

E. Cova, M. Colombo, M. Morosini, S. Inghilleri, S. Miserere, S. Magni, D. Prosperi,* F. Meloni* An innovative approach to selectively inhibit mesenchymal cells isolated from BOS patients. J. Heart Lung Transplant 2013, 32, S82.